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These pathways are commonly studied in experimental models to understand how peptide signaling influences adipocyte function and energy metabolism

Furthermore, research findings are difficult to compare and synthesize because of inconsistencies in methodology and significant differences in aspects such as dosage, method of administration, demographics, and study protocols

This is often seen as a last resort since it may produce dependence on the medication among patients

Biomed Pharmacother 122:109700

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CrossRef BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy Gidon J Bnhof, Gundega Sipola, Alexander Strom, Christian Herder, Klaus Strassburger, Birgit Knebel, Claudia Reule, Jan-Christoph Wollmann, Andrea Icks, Hadi Al-Hasani, Michael Roden, Oliver Kuss, Dan Ziegler BMJ Open.2022