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Colorectal cancer (CRC), as a highly prevalent malignancy worldwide, faces critical challenges in overcoming therapy resistance and recurrence

Immunosuppression, immunosenescence, and insulin resistance associated with inflammaging Immunosuppression increases with aging and age-related diseases Currently, it is known that a low-grade inflammatory process is associated with a compensatory anti-inflammatory state which involves the activation of the immunosuppressive network

Robbe D, Alonso G, Duchamp F, Bockaert J, Manzoni OJ (2001) Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens

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Kassube and Thoma, 2020)

For each condition, nuclei were pooled from 5 female and 5 male mice, with two replicates per condition (LPC: baseline = saline injected, demyelination = 7 dpl, CPZ: baseline = normal chow, demyelination = 5 weeks of 0.2% CPZ)