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Description

This occurs through the impairment of thioredoxin 2 (Trx2) activity, which subsequently triggers the release of a cascade of proapoptotic factors, including the notable cyclophilin D, thereby influencing the apoptotic pathways and cellular homeostasis

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Thus, those that inhibit System X c activity are able to inhibit GSH biosynthesis through Cys depletion

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Nrf1 and nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via Nf-Kappab and Ap-1

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PubMed PMID: 37074174

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