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Lactate secreted by these CAFs is taken up by tumor cells and facilitates histone H3K18 lactylation, which activates transcription of neural invasion-associated genes, such as L1CAM and SLIT1, thereby driving perineural invasion in pancreatic cancer [83]

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Stress-induced stress accumulation can occur locally in the root, where it is in direct contact with the stressor, but it can also travel to the tissue above ground

Acta 1820, 188202