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For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Zeng et al., 2016

The DA-PLGA were administered intraperitoneally at doses of 10 mg or 20 mg per animal in a 6-hydroxydopamine mouse model of PD

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The results revealed that S32A mutation in RIPK1 significantly increased the sensitivity of MEFs to death induced by TNF alone and resulted in RIPK1 kinase activation, which can be blocked by RIPK1 kinase inhibitor Nec-1s (Fig

jasminoides to maintain leaf vitality and metabolic integrity under prolonged ionic toxicity, exemplifying a steady-state adaptive mechanism characteristic of woody plants