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The enhanced drug bioavailability caused by piperine is due to its potent inhibition of drug metabolism, being able to inhibit human P-glycoprotein and CYP3A4, while it interferes with UDP-glucose dehydrogenase and glucuronidation activities in liver

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In hTYR, Although CME is a shorter tripeptide, it can pull the loop regions towards the pocket center, narrowing and occupying the pocket entrance

For example, oxidized cysteine (cystine) makes Salmonella enterica more sensitive to gentamicin by disrupting the intracellular redox balance, altered the GSH/GSSG ratio, raised ROS, and increased ferrous iron, which potentially fuels the Fenton reaction, all of which contribute to greater bactericidal activity