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ACSL4 (acyl-CoA synthetase long-chain family member 4) is a key positive regulator of ferroptosis that catalyzes the esterification of long-chain polyunsaturated fatty acids (such as arachidonic acid), converting them into acyl-CoA derivatives and thereby facilitating the synthesis of polyunsaturated phospholipids that are highly susceptible to lipid peroxidation

Specifically, diet-induced obese (DIO) mice exhibited diminished NAD + levels and impaired postprandial glucose metabolism compared to their lean counterparts

The enzyme has the capacity to reversibly bind heme, and a possible role in heme transport has been postulated

Consult your healthcare provider before starting any new supplement regimen, especially if you are pregnant, nursing, or have a medical condition

The effects of ferroptosis in eye diseases cannot be underestimated, with ferroptosis becoming a research target in ocular disorders and emerging evidence from a series of in vivo and in vitro researches into ferroptosis revealing its role in eye conditions

Reduction in hyperpigmentation: Dark spots, sun damage, acne scars, and melasma show clear improvement after a few sessions