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Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimers disease: Design, synthesis and biological evaluation

A double-blind randomized controlled trial testing an antioxidant combination treatment (vitamin E, vitamin C, and -lipoic acid) in Alzheimers disease patients reported that this treatment was associated with accelerated cognitive decline as measured by the MMSE, despite a decrease in the level of oxidative stress (F2-isoprostane) in the cerebral spinal fluid (CSF) (19)

R.YangJ.HillerK.et al

Therefore, the use of curcumin and cisplatin in combination for breast cancer treatment may have profound clinical implications, but further studies are still needed to ensure the effectiveness of this combination therapy in different breast cancer models and clinical treatments

Biochim Biophys Acta 1760:7077

In the center of a tumor, cancer cells are already facing a deficit of oxygen and nutrients