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Sirtuins are known as longevity proteins because of their noteworthy roles in stress resistance, metabolism, apoptosis and aging

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BPC-157 BPC-157 is a synthetic peptide from a protein found in gastric juice (stomach acid)

doi: 10.1142/s2575900020500093 430 Heidary MoghaddamRSamimiZMoradiSZLittlePJXuSFarzaeiMH

85 TGF-1 induces angiogenesis primarily by enhancing VEGF secretion under hypoxia and upregulating signaling proteins such as Smad3/4 and HIF1, which further increase VEGF transcriptional activity through histone acetyltransferase (p300), emphasizing the role of chromatin remodeling