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Description

In the cumulative toxicity test, Kunming mice were injected with 500 mg kg 1 LAAM GSH-CQDs on days 0, 4, and 7, respectively, and the dose was increased to 1000 mg kg 1 on days 10 and 13, with an accumulated dose of 3500 mg kg 1

On Monday, the FDA issued a Complete Response Letter for lebrikizumab due to inspection findings at a third-party manufacturer

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Acknowledgements We are grateful for financial support provided by the National Key Research and Development Program of China (2017YFD0200500), NSFC (21971065, 21722202, 21672069), the S&TCSM of Shanghai (18JC1415600), Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, National Program for Support of Top-notch Young Professionals, and Innovative Research Team of High-Level Local Universities in Shanghai

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Tumor markers like PSA, CA-125, or CEA may be worth checking in individuals with relevant risk factors, though their usefulness for screening in healthy individuals remains debated