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72 After internalization into cancer cells, the MnO 2 envelope undergoes a redox reaction with GSH, resulting in the formation of the oxidized form of GSH (GSSG) and Mn 2+ ions

Bcl-2 increases the respiratory rate and cytochrome oxidase activity which leads to the increase of superoxide production

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Holmgren, 2000), there is enormous overlap between the two pathways and, for the most part, general physiological equivalence of the two pathways