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J Biol Chem, 244: 5735-5744

The filopodia from adjacent tip cells make and break contacts many times during initial contact formation, after which VE-cadherin is deposited at a single point of filopodia contact and a ring shaped junction is formed to create a small luminal pocket at this site [22, 25, 27]

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Rare but serious risks include pancreatitis, gallbladder disease, and a thyroid C-cell tumor risk based on rodent studies (semaglutide carries a boxed warning and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2)