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Will all patients benefit from the same protocol, or do we need to characterize the clinical and neuropathological specificities of each patient more precisely to propose adapted therapy

Astrocytes have been implicated in neuropathic pain mediated by the GluGln cycle

P values were calculated using Students t -test

Although many antioxidant therapies targeting multiple sources of ROS in experimental models have shown promise, several clinical trials utilizing antioxidants appear to confer no significant protection [73, 135]

Biomolecular Concepts

How glutathione preserves NAD+, activates sirtuins, and may influence gene expression