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Hornak J, Rolls ET, Wade D

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The glyoxalase system is a GSH-dependent detoxification system in plants, where the glyoxalase I (Gly I

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doi: 10.1038/s44259-023-00016-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 21.Belay WY, Getachew M, Tegegne BA, et al

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however, in specific genetic contexts, its abnormal splicing or functional inactivation may lead to insufficient intracellular iron accumulation, thereby limiting Fenton reaction efficiency and attenuating radiotherapy-induced lipid peroxidative damage (196).Conversely, overexpression of ACSL3, a member of the long-chain fatty acid-CoA ligase family, enhances the activation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), promoting the synthesis of oxidation-sensitive phospholipids like AA-PE and significantly increasing membrane susceptibility to radiotherapy-induced lipid peroxidation (197)

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In bleeding patients, hemoglobin levels may not reflect tissue oxygenation as fluid shifts occur in parallel to transfusion

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