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and attention to cellular safety for chemistries such as slow Schiff-base formation and thiol radical reactions

This underscores the importance of responsible, measured protocols

Through the lens of genomics and molecular biology there is a great complexity inherent to cellular processes and their interactions, not to mention the pitfalls in variant filtering and classification, including potential errors in alignment, annotation, and variant calling, as well as the challenges of pathogenicity classification under ACMG/AMP guidelines (Richards et al., 2015)