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ENL R16 is surrounded by several CRBN residues in the N-terminal domain (F102, F150 and I152) and stacks between CRBN F102 and F150, whose relative positions suggest formation of a cation interaction (Fig

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de la Fuente M, Lombardero L, Gmez-Gonzlez A et al (2021) Enzyme therapy: current challenges and future perspectives

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Nevertheless, the clinical translation of Scrophularia radix in diabetes remains limited, as most studies are preclinical and lack rigorous clinical validation