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251 The PI3K/AKT pathway can also ameliorate the colonic inflammatory phenotype and inhibit the activation of CD4 + T cells by suppressing the glycolytic pathway, 252 and the activation of Akt signaling has been shown to promote mucosal healing

130 In fact, some data from non-human primate studies indicate that adenosine receptor antagonists, like caffeine, may allow for a reduced dosage of L-DOPA