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3.3 Risk assessment of bias in included studies Assessment of the 10 included trials using RoB 2.0 (Figure 2) revealed an overall risk of bias categorized as some concerns. Key methodological issues included inadequate randomization and allocation concealment, unclear blinding of outcome assessors, and potential selective reporting due to discrepancies between the registration protocol and the final published results

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Neuroinflammation 15:143

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J Biol Chem 280(40):3376633774 Lu SC (1999) Regulation of hepatic glutathione synthesis: current concepts and controversies

Development from Melanotan II The development of PT-141 emerged from research on Melanotan II (MT-2), a peptide originally synthesized for photoprotection and skin tanning through melanocortin-1 receptor (MC1R) activation