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Additionally, catalase was incorporated into the MOFs to mitigate the toxicity associated with H 2 O 2 produced by the reaction between Gox and glucose [328]

Harper & Schulman, 2021)

Key findings include: Significant and sustained reductions in glucose variability after Smart MDI activation Stable overall glycaemic indicator levels over time Favorable trends in time-in-range and reduced time-below-range metrics Highlights the potential of Smart MDI systems to support everyday diabetes management with meaningful outcomes over 12 months This study offers important real-world insights that bridge clinical practice and technology-enabled insulin delivery, contributing to a more nuanced understanding of long-term T1D management