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Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

To achieve this, there can be only two possibilities: (i) tumor cells may exhibit mechanism(s) removing malonyl-CoA but without directing it toward the fatty acyl synthase machinery, thus relieving carnitine palmitoyltransferase 1 inhibition, and/or (ii) cancers harbor a carnitine palmitoyltransferase 1 that is not sensitive to inhibition by malonyl-CoA

N-acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential

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Third, our recent study showed that mitochondrial ROS accumulation and their translocation into the nucleus marks the point of no return in the induction of oxidative ferroptosis [46]

Front Immunol 11:504077 Scherlie R (2020) Nasal formulations for drug administration and characterization of nasal preparations in drug delivery