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J Cell Mol Med 26(14):41134123 Li K et al (2021) Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression

FIGURE 4 8.1 Iron metabolism dysregulation Iron is unevenly distributed in the cerebral cortex: the metal burden in motor-related nucleiincluding the basal ganglia, amygdala, substantia nigra, hippocampus, and red nucleusis significantly higher than in other neural regions (Bartzokis et al., 2007)

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In 1968, in recognition of this important achievement, Nirenberg was named a co-winner of the Nobel Prize in Physiology or Medicine

Immunosuppressive therapy: Depending on the severity of the irAE, immunosuppressive medications, such as corticosteroids (e.g., prednisone) or other immunomodulatory agents (e.g., infliximab, mycophenolate mofetil), may be used to suppress the overactive immune response and control inflammation