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Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Pizzi M, Menga A, et al

Sharief MK, Hentges R (1991) Association between tumor Necrosis factor- and disease progression in patients with multiple sclerosis

An increasing number of studies have documented that failed lysosomal function is closely related to the occurrence and development of neurodegenerative diseases, including Gaucher disease, hereditary spastic paraplegias, and Alzheimers disease (AD) 18,123,124,125

2.2 Clinical diagnosis To date, there is a lack of established diagnostic standards for BIPN, which leads to a frequent underestimation due to patient underreporting and insufficient assessment by physicians (Park et al., 2019)