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Restoring endogenous GSH: activating G6PD Specifically, GSH depletion and increase in GSSG are hallmarks of bilirubin toxicity

doi: 10.1016/j.mad.2006.12.006

IACS-010759, a selective mitochondrial complex I inhibitor, reduces tumorigenicity in acute myeloid leukemia models dependent on oxidative phosphorylation, with enhanced efficacy under glucose-restricted conditions