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It acts as a physiological ligand for Fe 2 + , promoting assembly of iron-sulfur (Fe-S) clusters and biosynthesis of Fe-S proteins, which participate in essential biological functions including electron transfer, the Krebs cycle, maintenance of genome integrity, enzymatic catalysis, and iron homeostasis 15

Table 3 The role of nutrigenomics, nutri-epigenetics and diet - gut microbiome axis in influencing ART outcomes

GHK-Cu# GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) functions primarily through its copper-chelating properties and broad gene-modulatory effects

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This is the minimum timeframe for meaningful change, consistent with the clinical trial data