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The stacking approach is the most common protocol in the research community for this reason

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Hou X, Du Q, Li R, Zhou M, Wang H, Wang L, et al

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Though the protection is localized to the ER, it potentially extends to the cytosol by preventing consumption of reduced glutathione (discussed below), which is a major cytosolic and mitochondrial antioxidant

Glia 63:365382 Carretero J, Obrador E, Pellicer JA, Pascual A, Estrela JM (2000) Mitochondrial glutathione depletion by glutamine in growing tumor cells