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The disease is caused by the abnormal expansion of the GAA repeat sequence in intron 1 of the FXN gene, leading to the reduced expression of the mitochondrial protein frataxin

An in vivo study by Devamanoharan et al (45) found that a 0.3 mM per rat pup/day intraperitoneal vitamin C injection maintained ATP and GSH levels and decreased MDA (the end product of LPO) levels to prevent nuclear cataract development

Additionally, sarcopenia is an independent risk factor for progression to end-stage renal disease and hospitalization in CKD patients

doi: 10.1038/s41418-021-00814-y 61

Immunofluorescence Microscopy: Utilizing fluorescently labeled antibodies that target S-glutathionylated proteins enables the visualization of S-glutathionylation within cells or tissues

Injectable routes typically provide more consistent systemic exposure and may be preferred for non-gastrointestinal applications requiring tissue delivery beyond the digestive tract