human glutathione s transferases Schematic representation of the structure of a Glutathione S-Transferases: Structure, Function and

Nature 585 , 273276 (2020)

We explored the effects of anti-oxidant, N -acetylcysteine (NAC) on the accumulation of methaemoglobin

Furthermore, if another pathology emerges in the future for the same patientfor example, a tumorthe MDT, expanded to include an oncologist and a pathologistcan rapidly analyze genes associated with hereditary cancer, using the same dataset

2 In terms of biochemistry, it is mainly involved the increase of reactive oxygen species (ROS), decreased activity of glutathione peroxidase 4 (GPX4), iron disorder and accumulation of lipid peroxidation

Palmitate-induced lipotoxicity increases ROS production and hepatocyte death in SIRT3-deficient primary hepatocytes [184]

Further studies from the same group revealed that fermented rooibos extract has a potential for preventing obesity by inhibiting adipogenesis in differentiating 3T3-L1 adipocytes [254] and also showed cardioprotective effect in isolated cardiomyocytes derived from diabetic rats, subjected to experimentally-induced oxidative stress and ischaemia [255]