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When acetylcarnitine is injected directly into the brain, most of the acetyl groups were metabolized, as 60% of the injected acetylcarnitine was recovered as exhaled 14 CO 2 after 22 h, and the percentage recovered in the brain was 1.9, 1.6, 1.3, and 0.9% at 1, 3, 6, and 22 h, respectively [109]

Front Mol Biosci

Nine trials were conducted in participants with overweight and/or obesity (Reference Ahmed Al-Naggar, Osman and Abdulghani23,Reference Alperet, Rebello and Khoo24,Reference Basu, Betts and Mulugeta26,Reference Cardoso, Salgado and Cesar28,Reference Kobayashi, Kawano and Ukawa31,Reference Mousavi, Vafa and Neyestani35,Reference Nabi, Sedighinejad and Haghighi37,Reference Ohnaka, Ikeda and Maki38,Reference Wedick, Brennan and Sun44) and nine in healthy participants (Reference Ahmed Al-Naggar, Osman and Abdulghani23,Reference Hochkogler, Schweiger and Rust29Reference Lecoultre, Carrel and Egli32,Reference Revuelta-Iniesta and Al-Dujaili39,Reference Superko, Bortz and Williams40,Reference van Dusseldorp, Katan and van Vliet42,Reference Wedick, Brennan and Sun44)

Evidence for this treatment showed an inconclusive trend of efficacy

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45 Gastrointestinal side effects are the most frequently reported side effects associated with oral zinc supplementation, 46 the most common among them being nausea reported in up to 25 percent of patients