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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

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The possible cytoprotective effects of the application of NaBPC157 were studied based on their effect on the initial Robert's model for a cytoprotective-agent screening of the ethanol-induced gastric lesions