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Supplementation of culture media with Cu sulfate failed to restore mitochondrial respiratory function in hSOD1 G93A transfected NSC34 cells

Lei, M, Overman, MJ, Yao, J, Andre, T, Lonardi, S, Lenz, HJ, Aglietta, M, Gelsomino, F, Mcdermott, R, Wong, KM, Morse, MA, Van Cutsem, E, Hendlisz, A, Cardin, D, Neyns, B, Hill, A, Krishnamurthy, A, Chen, F, Kochuparambil, ST, Jenq, RR, Abdullaev, S, He, B, Novosiadly, R, Kopetz, S

Primary Rest- deficient RTECs were also isolated and cultured from Rest RTKO mice for lipid ROS detection, which showed a significant aggravation when Gclm was knocked down (Figure 4K and Supplemental Figure 12F)

Another consideration is whether to take glutathione directly or support the bodys own production

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PMID: 39699076