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To maintain amino acid nutrition for tumor growth, the expression of the LAT1 ( SLC7A5 ) transporter is controlled by the pro-carcinogenic transcription factors c-Myc (Yue et al., 2017), HIF2 (Elorza et al., 2012), and NOTCH (Grzes et al., 2017), as well as the post-transcriptional regulator miR-126 (Miko et al., 2011)

The free peptide is usually represented with an unmodified amino terminus and a C-terminal carboxylic acid

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doi: 10.1186/s13048-021-00867-0 20 DengHChenYXingJZhangNXuL