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Additionally, FOXO transcription factors have recently been implicated in tumorigenesis: in fact, rhabdomyosarcomas present FOXO genes with a high percentage of mutations that render them insensitive to inhibition by AKT signaling 65

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As a drug delivery system, nano gels have several advantageous features for the PD, like high drug loading capacity, biocompatible nature, and safeguarding the encapsulated drugs from degradation (137, 138)