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Recent studies suggest that PS-NPs disrupt glutamate cycling by suppressing astrocytic EAAT2, resulting in aberrant synaptic transmission and excitotoxic neuronal damage

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Curr Treat Options Psychiatry 2016;3:133-50

Schiller et al

For some reason one of the three arrangements possible for the other two structures could have been less stable or harder to prepare and had simply not yet been synthesized

In a narrow range of pH, the structural and morphological changes of enzymes and substrates may be reversible