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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

However, resistance and relapse in patients have sparked interest in novel approaches using sdAbs derived from camelid species, which have favorable properties that can potentially overcome the limitations of traditional monoclonal antibodies

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Lian, J., van der Veen, J

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