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Hence, by targeting the enzymatic activity of SARM1, inhibitors may effectively prevent the depletion of NAD + , thereby maintaining cellular energy homeostasis and enhancing neuronal resilience, potentially expanding the treatment landscape for various neurological conditions

However, inhibitors of autophagy, necroptosis and apoptosis only partially improved survival substantially, suggesting that ferroptosis is essential for DOX-induced cardiomyopathy and mortality in mice [91]

This can be valuable as estimates within large cohorts but likely less reliable to understand the true distribution of data sets

Novel Role of the SIRT1 in Endocrine and Metabolic Diseases

Crit Rev Food Sci Nutr 60:27732789

Higher doses may be beneficial for those with chronic health conditions