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Enhanced neuronal survival and axon growth (suggested by activation of the PI3K/Akt and MAPK pathways) with lower inflammation (suggested by reduced p38 and JNK phosphorylation) were also recognized ( Finally, Several studies demonstrate that the functionalization of RADA 16-I hydrogels with bioactive motifs derived from neurotrophic factors (e.g., NGF, BDNF), angiogenic peptides (e.g., VEGF-mimetic KLT), and ECM-related sequences (e.g., IKVAV, RGD, RGI) significantly enhances peripheral nerve regeneration versus unmodified RADA or empty conduits