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Option (Evidence Strength: Grades B, B, C, and B) Amitriptyline (Evidence Strength: Grade B ) One randomized controlled trial reported efficacy of oral amitriptyline (25 mg daily titrated over several weeks to 100 mg daily if tolerated) to be superior to placebo (63% of treatment group clinically significantly improved compared to 4% of placebo group) at four months

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Nasal health Severe congestion, allergic rhinitis, or acute upper respiratory infections can reduce absorption

Evidence has revealed that BA exhibits a variety of pharmacological features such as neuroprotective, anticancer, antioxidant, anti-inflammatory, cardioprotective, eye protective, as well as hepatoprotective properties (Sowndhararajan et al., 2017)

The accumulation of excessive ROS can induce cellular damage (6062), impairing tissues and organs normal functioning

Nature 429 , 417423 (2004)