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Organ crosstalk and dysfunction in sepsis

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Since excessive infiltration of mobile pro-inflammatory cells such as macrophages and T-helper 17 cells has been found in lung tissues of patients with COVID-19 (11), it appears at least possible that SARS-CoV-2 can apply a strategy that was considered unique to HIV-1: triggering local inflammation to attract mobile immune cells and infect these cells to achieve systemic distribution throughout the host

Prevention of radical generation might be crucial during the chelation of metals, which can damage target biomolecules (Kumar et al., 2013a

The main antioxidants associated with GPX4, GSH and its precursor NAC, play a crucial role in inhibiting ferroptosis by enabling GSH to reduce lipid hydroperoxides to non-toxic lipid alcohols (Maiorino et al., 2018)

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