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Li X, Schuler MA, Berenbaum MR

Many cells and virtually all tissues express several NOX isoforms

In the context of nanomaterials, factors such as particle size, dosage regimen, administration route, surface chemistry, degree of aggregation, transmembrane diffusivity, excretion mechanisms, and immunogenic potential are the key determinants of nanotoxicity

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SUBLOCADE forms a solid mass upon contact with body fluids and may cause occlusion, local tissue damage, and thrombo-embolic events, including life threatening pulmonary emboli, if administered intravenously