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MOTS-c also increases the OPG/RANKL ratio in osteoblasts

PPAR site-directed mutagenesis A pEF-BOS plasmid containing murine Ppara gene, as described in a previous literature 43 , was utilized to generate PPAR mutant constructs

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Therefore, more in-depth research is required to focus on the role of ferroptosis in the development of DKD, which is of great significance for the clinical diagnosis and treatment of DKD in the future

P53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function

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