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Furthermore, the OA-associated acidic microenvironments (pH 6.67.2) promote M1 macrophage polarization through altered glucose metabolism, thereby augmenting their pro-inflammatory activity [11]

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*Correspondence: Suraj Unniappan, [email protected] This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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