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In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]

In summary, SCLC cells suppress ROS defense enzymes through yet unidentified but very likely overlapping layers of epigenetic and transcriptional mechanisms

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The defective mitochondrial biogenesis is driven by the upregulation of the Parkin substrate PARIS and the subsequent downregulation of PGC-1 (Ge et al., 2020)