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doi: 10.1016/j.biopha.2022.114048

However, some tumor cells can use glutathione peroxidase 4 (GPX4), a lipid repair enzyme, to decrease LPO accumulation by converting toxic LPO to non-toxic lipid alcohols in the presence of glutathione (GSH), thereby protecting themselves from ferroptosis [18, 19]

Kang L, Zheng HX, Zhang M, Yan S, Li L, Liu L, et al

Synthetic chemistry See supplementary method file

Each spray delivers 166mcg, providing a consistent and easy-to-manage dosing approach

The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14