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Striatal dopamine levels reached 7.14 1.19 ng/mg tissue, alongside significant increases in metabolites such as homovanillic acid (3.59 0.51 ng/mg compared to 1.93 0.43 ng/mg in controls) and 3,4-dihydroxyphenylacetic acid (13.43 1.62 ng/mg compared to 8.97 1.49 ng/mg in controls)

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It is inconceivable that Butz and du Vigneaud could have anticipated the relevance of their discovery in relation to so many diverse diseases and disorders

To overcome these barriers, future research must shift toward precision intervention that bypasses broad metabolic disruption in favor of selective molecular targeting