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30 Therefore, different TP53 pathways utilize different ALOXs to induce ferroptosis (Fig

By utilizing this characteristic, NPs are designed to traverse the BBB through receptor-mediated transcytosis by binding to TfR1, thus achieving specific targeting and killing of glioma tumor cells ( Drugs that respond to the TIME to specific stimuli, such as pH-sensitive or matrix metalloproteinase-activated systems, can also increase local drug activation (184)

Migliavacca" Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, (4)Foundation Irccs Ca Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, (5)Department of Transfusion Medicine and Haematology, Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico, (6)Section of Gastroenterology and Hepatology, Dipartimento Di Promozione Della Salute, Materno Infantile, Medicina Interna e Specialistica Di Eccellenza (PROMISE), (7)Sezione Di Gastroenterologia, Dipartimento Promozione Della Salute, Materno-Infantile, Di Medicina Interna e Specialistica Di Eccellenza G