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In developed countries, situations at greatest risk for deficiency include eating a diet restricted in fruits and vegetables, smoking or long-term exposure to secondhand smoke, and drug and alcohol abuse

Future research on cuproptosis in cardiovascular diseases should advance along these critical paths

Researchers have also explored its effects on reducing the appearance of fine lines, improving skin tone, and supporting barrier recovery after environmental stress

J Clin Endocrinol Metab 78(6):12981306 Postel-Vinay MC, Tar A, Crosnier H, Broyer M, Rappaport R, Tonshoff B, Mehls O (1991) Plasma growth hormone-binding activity is low in uraemic children

While there are many vegan sources of B12 in food, Viva