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Together, our findings suggest that hyperhomocysteinemia has a role in the onset, development, and progression of PD neuropathology, directly inducing dopaminergic neuron degeneration or indirectly activating inflammatory signaling pathways

Wang M-H, Sun R, Zhou X-M, Zhang M-Y, Lu J-B, Yang Y, et al

Genotype, enzyme activity, glutathione level, and clinical phenotype in patients with glutathione synthetase deficiency

Antioxidants 9:465

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Mutagenesis experiments were carried out according to the instructions of the QuikChange Site-Directed Mutagenesis (SBS Genetech Co., Ltd, Beijing, China)