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4 Metabolic interactions in the hepatocellular carcinoma tumor microenvironment 4.1 Metabolic crosstalk between hepatic stellate cells and hepatocellular carcinoma cells Cancer cells maintain an alkaline intracellular environment by undergoing aerobic glycolysis, which generates a large amount of protons that are transported to the extracellular space through upregulation of H+ transport proteins

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Resistance to antimalarials creates a great hurdle toward treatment

The second step of GSH biosynthesis is catalyzed by glutathione synthetase, which adds glycine to the preformed -glutamylcysteine dipeptide

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11 An increased concentration of TRX-1 had a positive effect on the activity of other antioxidants such as manganese superoxide dismutase and GSH peroxidase