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It is important to note that gastrointestinal side effects typically diminish over time as the body adapts to the medication

In children, therapy may continue for several years until an acceptable height is achieved or until growth plates close

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Proper Oral Hygiene: Practising proper oral hygiene, such as brushing your teeth and tongue regularly, can help prevent the darkening of the lips

Possibly the extended and vertical shape in MGST1 allows the conjugation of second substrate within the enzyme in contrast to MPGES1 where most of the substrate appears to remain outside the protein in the lipid bilayer (PDB IDs 4AL1, 4YL0, 5BQH, 5BQG, 5K0I)

Schurr, 2025)