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Langton KP, McKie N, Curtis A, Goodship JA, Bond PM, Barker MD, Clarke M (2000) A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsbys fundus dystrophy

It is metabolized in the liver and it is excreted in the urine, bile and secretions

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To further complicate matters, the study states: "no clear optimal [pH range] was seen when the test was run without [fatty acid byproduct]." It was only used to compare how animal and human skin metabolises the form of vitamin A naturally present in the skin, not about how topical vitamin A (retinol) benefits the skin

10.1021/acs.est.2c02575 [DOI] [PubMed] [Google Scholar] Warnes S

These systems also protect fragile antigenic materials from enzymatic breakdown within the body, ensuring that the immune system encounters them in their active form